Effects of Quercetin on Muscle-Type Nicotinic Receptor Activation and Desensitization

摘要

We have studied, for the first time to our knowledge, the effects of Quercetin (OCT), a natural flavonoid, on the activation and desensitization behavior of the muscle-type nicotinic receptors natively expressed by the TE 671 cell line. The effect of OCT was assessed by means of the patch- clamp technique, in the whole-cell configuration. The application of QCT in the bath solution, at concentrations between I and 50 uM, influenced the whole-cell currents induced by 10 uM Ach in which regards peak current amplitude, activation and desensitization kinetic. The magnitude of the observed effects depended on the duration of exposure and on the OCT concentration in a non-linear fashion. Our data show that QCT influences the kinetic parameters related to the muscle-type nicotinic receptors activation and desensitization.