The Impact of Topical Recombinant Growth Hormone on Wound Healing

摘要

Objective. In an effort to improve the wound healing of the ear, the influence of topical recombinant growth hormone was investigated, using hyaluronic acid as biomaterial, on ear burned wounds in rabbits. Material and Methods: 15 New Zeeland male rabbits have been used. A deep 2nd degree burn was inflicted on each ear. On the control side, only hyaluronic acid gel was applied and on the study side, a combination of hyaluronic acid and chicken recombinant growth hormone. The dressings were changed every other day for two weeks. Glycaemia and IGF-1 levels were monitored. On the 10th week, biopsies were harvested for histological and immunohistochemical examination. Results. No differences in serology before and after topical administration of chicken recombinant growth hormone have been observed. Lower degree of inflammation (p<0.05), increased amount of collagen (p<0.05), vascularization (p<0.05), respectively myofibroblasts activity were observed on the study side. Conclusion. The wound healing was improved significantly by topical administration of chicken recombinant growth hormone.