Immunoexpression of PCNA and α-SMA in gingival overgrowth tissues

摘要

Purpose: This study aimed to investigate proliferating cell nuclear antigen (PCNA) and isoform-α?of the smooth muscle actin (α-SMA) immunoexpression, as well as the epithelial thickness in druginduced?gingival overgrowth (DIGO) and idiopathic gingival fibromatosis (IGF) patients. Methods: Gingival samples were obtained from 11 users of nifedipine and phenytoin, 6 of patients with?IGF and 4 fibrous inflammatory hyperplasia. The specimens were submitted to immunohistochemical?and morphological analysis. Results: Our results show that PCNA-epithelial positive cells were slightly more common among?IGF patients, but there were not statistically significant differences among the groups (p&0.05).?Comparing the vessels counts with α SMA-positive pericyte or smooth muscular cells, there was not?statistical differences, although the control group presented a discrete higher count (p&0.05). The?epithelial thickness analysis revealed that the DIGO group presented the higher mean, evidencing?statistically significant differences in relation to the control group (p=0,002). Conclusion: In conclusion, our results demonstrated similarities between DIGO and IGF according?to PCNA and α-SMA immunoexpression, although the epithelial thickness was higher in DIGO group.