A COMMERCIAL VIABLE PROCESS FOR THE PREPARTION OF SUBSTANTIALLY PURE AMORPHOUS FORM OF PROTON PUMP INHIBITORS

摘要

A commercially viable process is being developed for the prepartion of substantially pure amorphous form of proton pump inhibitors such as of sodium, calcium, magnesium and potassium salts of rabeprazole, pantoprazole, omeprazole and lansoprazole. The process consist of performing ball-milling of crystalline proton pump inhibitors such as of sodium, calcium, magnesium and potassium salts of rabeprazole, pantoprazole, omeprazole and lansoprazole. The amorphous form of proton pump inhibitors such as of sodium, calcium, magnesium and potassium salts of rabeprazole, pantoprazole, omeprazole and lansoprazole is being characterized by powder X-ray diffraction pattern.