SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIALSTUDIES OF 1-(5-BROMO-2-HYDROXYPHENYL)-3-(4-BROMOPHENYL)-PROPANE-1,3-DIONE AND THEIRTRANSITION METAL COMPLEXES

摘要

A new ligand 1-(5-bromo-2-hydroxyphenyl)-3-(4-bromophenyl)-propane-1, 3-dione have been synthesized from 5-bromo-2-hydroxyacetophenone and 4-bromo benzoic acid. Their transition metal complexes have been synthesized.1, 3-dione or ligand co-ordinate with the transition metal ions through oxygen atoms. The stiochimetry ratio ligand tometal has been 2:1. The synthesized 1,3-dione and their transition metal complexes have been characterized by 1HNMR,13C-NMR,IR,Elemental analysis, Powder XRD, TGA. Solution conductivity, Magnetic susceptibility andAntimicrobial screenings were also studied using Resazurin 96 well plate method. Tetracycline and Amphotericin Bare used as standard drugs. The transition metal complexes showed moderate to excellent antimicrobial activity againstall tested bacteria and fungi.