Theoretical and conceptual proposal for appearance modeling of ossification centers in different types of flat and long bones

摘要

A work context on the modeling of endocondral formation process in any type of ossification present in the bones of the human body was shown. Assuming that PTHrP and Ihh form a biochemical regulatory loop for the endocondral process and BMP2 and Noggin for the intramembranous one, regulatory mechanisms for this formation process were implemented. For this purpose, a set of widely used diffusion reaction equations in morphogenesis were used in which the biochemical factors are supposed to be secreted by precursor cells, mesenchymal and chondrocytes in the case of intramembranous and chondroidal respectively. It was concluded that the solution led to the denominated Turing patterns which represent these ossification processes in a highly estimated form.