首页> 外文期刊>Revista colombiana de obstetricia y ginecologie >Exactitud del test ADN-HPV para la detección de la enfermedad cervical de alto grado (NIC 2+) en mujeres con anormalidades citológicas (ASC-US y LSIL), afiliadas a la seguridad social en Bogotá (Colombia)
【24h】

Exactitud del test ADN-HPV para la detección de la enfermedad cervical de alto grado (NIC 2+) en mujeres con anormalidades citológicas (ASC-US y LSIL), afiliadas a la seguridad social en Bogotá (Colombia)

机译:DNA-HPV检测在患有细胞学异常的妇女(ASC-US和LSIL)中检测高级别宫颈疾病(CIN 2+)的准确性,该疾病与波哥大(哥伦比亚)的社会保障有关

获取原文
获取外文期刊封面目录资料

摘要

Objective: evaluating the accuracy of the HPV DNA test as a complementary test for diagnosing highgrade cervical disease (high-grade squamous intra epithelia lesions-HSIL) in women with minor cytological abnormalities (atypical squamous cells of undetermined significance ASC-US) and low-grade squamous intraepithelial lesions (LSIL). Methodology: a diagnostic validity study based on a cross-sectional design was applied to 429 women who had had a cytological report of ASC-US and/or LSIL who were attending a health maintenance organisation’s cervical cancer screening programme in Bogotá, Colombia between January 2006 and October 2008. Colposcopy reports and HPV-DNA testresultswerecomparedwithpathologicalreports which were considered the gold standard. Results: 344 (80.2%) of the 429 women had a cytological report of ASC-US and 85 (19.8%) of them one for LSIL. High-risk HPV infection prevalence was 52.9% and 75.7% in patients having an ASC-US and LSIL report, respectively. A biopsy specimen was obtained in 379 of the 429 participants and 24 high-grade cases (6.3%) were diagnosed. DNA-HPV test sensitivity was 88% and specificity was 44% for detecting high-grade disease (CIN 2+) in women having an ASC-US and LSIL cytology report . The presence of high-risk HPV virus was detected in 21 of the 24 HSIL cases (87.5%). Conclusion: the DNA-HPV test’s higher sensitivity compared to the PAP smear (due to high NPV) means that it could be considered a useful tool for stratifying risk and improving the diagnostic approach to premalignant lesions of the uterine cervix in patients having a cytological report of ASC-US.
机译:目的:评估HPV DNA检测作为补充检测的准确性,该检测可用于诊断具有轻微细胞学异常(意义不明的非典型鳞状上皮细胞,ASC-US)的女性高度宫颈疾病(高度鳞状上皮内病变-HSIL)鳞状上皮内病变(LSIL)。方法:基于横断面设计的诊断有效性研究应用于2006年1月至哥伦比亚波哥大参加健康维护组织宫颈癌筛查计划的429名ASC-US和/或LSIL细胞学报告的妇女和2008年10月。阴道镜检查报告和HPV-DNA测试结果与被认为是金标准的病理报告进行了比较。结果:429名女性中有344名(80.2%)有ASC-US的细胞学报告,其中有85名(19.8%)具有LSIL的报告。有ASC-US和LSIL报告的患者高危HPV感染发生率分别为52.9%和75.7%。在429名参与者中的379名中获得了活检标本,并诊断出24例高级别病例(6.3%)。 DNA-HPV检测敏感性为88%,特异性为44%,用于检测有ASC-US和LSIL细胞学报告的女性高级别疾病(CIN 2+)。 24例HSIL病例中有21例检出高危HPV病毒(占87.5%)。结论:DNA-HPV检测比PAP涂片检查具有更高的灵敏度(由于NPV高),意味着它可以被认为是对有细胞学报告的患者进行子宫颈癌前病变的危险分层和改进诊断方法的有用工具ASC-US。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号