Carcinoma sebáceo asociado al síndrome de Muir-Torre: a propósito de un caso

摘要

The Sebaceous Carcinoma (SC) is an uncommon malignant tumor formed by cells that show differentiation toward sebaceous epithelium. It usuallyoccurs in women of average at 70 years of age. We report a case of a 69 years old female with a family history of multiples cancer, breast cancer andthe emergence of multiple sebaceous adenomas and carcinomas, features consistent with Syndrome Muir Torre (SMT). The 75% of the SC are locatedin the ocular region and the 25% rest presents extraocular location. The eye location is characterized by aggressive behavior, with direct extension andhigh potential for regional and distant metastases. Extraocular are generally less aggressive tumors and are located mainly in the head and neck. Thepathogenesis is unclear, but chronic inflammatory processes, ultraviolet radiation and radiation will favor its development. The SC is a versatile tumor thatpresents with different clinical and histological different growth patterns, which retard the definitive diagnosis. SC is one of the cutaneous diagnosticmarkers of SMT, which is a genetic disease associated with visceral neoplasms. They are carefully assessed, performing a proper personal and familycancer history. The treatment of choice is the surgery with wide margins.