Bialystok osteoporosis study-2: epidemiology of osteoporotic fractures and 10 year fracture risk assessment in population of women in Bialystok region by FRAX? – WHO algorithm

摘要

In a randomized cohort of postmenopausal women representative for Bialystok Region BOS-1 we found 14.8% of osteoporosis, 43% of normal results and 42.2% of osteopenia, while 30% of them reported low trauma fractures. 50% of Fx occurred in osteopenic BMD, 24.5% in normal and 25.5% in osteoporotic one. Mean Hip T-score of all Fx was –1.6. In a non-selected cohort of 1608 women in BOS-2, all clinical, independent, risk of fracture (FxRF) were included to evaluate population ten-year probability of major osteoporotic Fx – (hip, clinical spine, forearm or proximal humerus) (m.o.Fx.) as well as hip Fx (h.Fx.) with and without BMD measurement using FRAX?BMI and FRAX?BMD, a WHO Algorithm on the basis of epidemiology in women of the U.K. Results: 10 year probability of m.o.Fx. increased with age from 5.2% with BMD and 4.8% without BMD in the 5th decade to 23.9% and 29.5% respectively in the 9th decade, mean 11.8% with and 11.0% without BMD, and h.Fx from 0.4% and 0.5% to 11.4% and 15.4% mean 3.1% with and 2.8% without BMD respectively. 71% of women with Fx have BMD above hip T-score –2.5 and 18% of those without Fx have BMD below hip T-score –2.5. The results of BOS-1 and BOS-2 studies of epidemiology of osteoporotic fractures indicated that 10-year risk of fracture but not “densitometric osteoporosis” should be diagnostic and therapeutic tool for decision making health care subjects.