Comparative Therapeutic Efficacy of Imidocarb Di-Propionate and Diminazene Aceturate in Rats Experimentally Infected with Trypanosoma brucei

摘要

Diminazene aceturate is a yellow to orange aromatic diamidine compound with both antibacterial and protozoal activities. Diminazene aceturate is one of the most important drugs used in the treatment of trypanosomosis in animals. It is often used in treatment of Babesia and Trypanosoma species in animals. Over the years, consistent use of diminazene aceturate especially at low doses by quacks made provisions for development of resistant strains of trypanosome species and relapses of infection few days post treatment. The present challenge in chemotherapy in trypanosomosis necessitated the search for alternative therapies in both humans and animal patients. This study experimentally demonstrates the efficacy of imidocarb dipropionate in treatment of trypanosomosis. Its administration at the dose of 24 mg kg?1 subcutaneously for 2 consecutive days had a curative effect on rats with experimental Trypanosoma brucei infection. There was no relapse recorded in the treated group till the last (12th) day of the experiment. The present study threw some light on the potentials of imidazole dipropionate as an alternative therapy in trypanosomosis. It however requires a much detailed research to confirm its potency as a trypanocid.