Relation of Microalbuminuria and Coronary Artery Disease in non Diabetic Patients

摘要

Prospective studies confirm that microalbuminuria is predictive, independently of classical risk factor of cardiovascular disease events and all-cause mortality within groups of patients with diabetes or hypertension and in the general population. However, there are few data linking angiographic severity of Coronary Artery Disease (CAD) to Microalbuninuria (MA). We examined coronary angiograms for extent of severe CAD (luminal narrowing 50%) in patients without Diabetes Mellitus (DM) and general population. Our study consisted of 153 patients who undergoing coronary angiography in Hazrat Fatemeh hospital in Iran. (M/F 80/73, mean age 57?11y). Urine albumin excretion was measured in 24 h urine samples by immune precipitation technique. Age-sex, distribution of coronary risk factors and MA was compared between patient with and without CAD. 70/5% (108) of patient had CAD and 29/4% (45) had no coronary lesion. MA was detected in 62.9% in patients with CAD and 8.8% in those without coronary Artery lesion (p<0.05). The presence of 1 or 2 vessel CAD showed a linear increase from group to group without microalbuminuria (p<0.5). Thus, patients with MA have more severe angiographic CAD than those without MA. This relation is independent of other risk factor.