Antimicrobial studies of novel 2, 5 Dimercapto-1, 3, 4 thiadiazole derivatives

摘要

A series of novel chalcone derivatives of 2, 5 -Dimercapto-1, 3, 4 -thiadiazole (3a-h) were synthesized by Claisen-Schmidt condensation between terephthaldehydyl -2, 5 -dimercapto (acetichydrazide)-1, 3, 4 -thiadiazole (1) and substituted aromatic ketones (2a-h). All the synthesized compounds (3a-h) were characterized by UV, IR, 1H-NMR, 13C-NMR and mass spectral data. The synthesized compounds were subjected to antibacterial studies against Staphylococcus aureus, Bacillus subtilis (gram-positive), Escherichia coli and Salmonella enteritidis (gram-negative) bacteria and antifungal studies against Candida albicans, Trichophyton rubrum, Trichoderma viride and Aspergillus niger and the Minimum Inhibitory concentration of each compound was determined by liquid broth method. The results indicated that all the synthesized compounds 3a-h showed considerable antibacterial and antifungal activities.