A New Dibenzofuran from the Barks of Sorbus commixta

摘要

A new dibenzofuran derivative, 1,2,4-trimethoxydibenzofuran-3,9-diol (7) , was isolated from the ethyl acetate fraction of Sorbus commixta barks, along with six known compounds, lupeol (1) , betulin (2) , betulinic acid (3) , ursolic acid (4) , b -sitosterol (5) and b -pyrufuran (6) . Their structures were determined by NMR spectroscopic analysis, including of 1H and 13C NMR, 1H- 1H COSY, HSQC and HMBC spectra data. Cytotoxic activities of seven compounds were evaluated in five cancer cell lines, HEp-2, A549, MCF-7, PC-3 and SKOV-3 at the concentrations ranging from 10 to 100 m M.