Objective: Multiple system atrophy (MSA) is a neurodegenerative disease characterized by a combination of parkinsonism, cerebellar ataxia, andautonomic deficiency symptoms. The purpose of this study is to assess clinical characteristics of patients diagnosed with probable MSA and reviewdiagnostic challenges of MSA in view of the literature.Material and Method: Eleven patients followed-up with probable MSA diagnosis according to the second consensus statement on the diagnosis ofMSA criteria were included in the study. Patient files were reviewed retrospectively and the latest clinical examination characteristics were noted.Results: The mean age of eleven MSA patients was found to be 65.36 (±5.32). Six patients were female. The average disease time was 4 years. Tenpatients were not diagnosed with MSA by the clinician when they applied with the onset of symptoms. Only one patient was diagnosed with MSAcorrectly. Seven out of ten patients were diagnosed with Parkinson's Disease, whereas the other three patients were diagnosed with ataxia.Conclusion: A considerable number of patients are not correctly diagnosed with MSA during their lifetime due to difficulties in differentiating it fromother diseases. It is necessary to discuss this issue in the light of existing diagnostic criteria.
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