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Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis

机译:晚期慢性粒细胞白血病伴继发性淋巴细胞和骨髓幼细胞爆炸危机的差异细胞遗传学特征

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Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase and increases to 40–70% in advanced disease. Progression of CML from chronic phase to accelerated phase or blast crisis is often associated with secondary chromosomal aberrations. We report an exceptional case of CML as debut in lymphoblastic blast crisis and a subsequent progression in myeloblastic blast crisis with rare cytogenetic abnormalities.
机译:慢性粒细胞白血病(CML)中其他染色体异常的发生频率在慢性期估计为7%,而在晚期疾病中则增加到40-70%。 CML从慢性期发展到加速期或胚芽危机通常与继发性染色体畸变有关。我们报道了CML的一个例外情况,它是在淋巴细胞母细胞危机中首次出现,随后在骨髓母细胞母细胞危机中进展,并伴有罕见的细胞遗传学异常。

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