Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature

摘要

The t(4;12)(q12;p13) in acute myeloid leukemia (AML) is a rare finding with less than 30 cases described in the literature. The few cases reported show that this subtype of AML features dysplastic changes in all three cell lines, positivity for CD7, lymphoid appearing myeloblasts, basophilia, and low or absent myeloperoxidase activity [1,2]. Cases have been described in the literature as far back as 1989 [1], but prognosis remains poor with intensive chemotherapy alone. Here, we describe a case of an elderly patient with AML with t(4;12)(q12;p13) with extramedullary involvement who underwent an allogeneic stem cell transplant (alloSCT).