Potentially important miRNAs in enteropathy-associated T-cell lymphoma pathogenesis: A pilot study

摘要

Enteropathy associated T-cell lymphoma (EATL) is a rare form of NonHodgkin Lymphoma occurring primarily in the intestinal tract and whicharises from intra-epithelial T-lymphocytes (IELs) [1]. Previously known asType 1 EATL, this lymphoma has a strong association with coeliac diseaseand occurs with a higher frequency in Northern Europe where coeliac disease is most prevalent. Morphologically the lymphoma cells primarilyconsist of medium-sized to large tumour cells with round or angulated vesicular nuclei, prominent nucleoli, and pale-staining cytoplasm and is oftenassociated with a moderate to abundant reactive infltrate of eosinophils,histiocytes, and small lymphocytes [2]. These lymphomas are characteristically CD56 negative but may express CD30. Prior genetic studies haveshown that homozygosity for HLA-DQ2 (HLA-DB1*02) and allelic variantsof the MYO9B gene region maybe associated with previously classifedEATL and indeed, data from comparative genomic hybridization studies ontumour DNA suggest that chromosomal gains of 1q and 5q and segmentalamplifcation of 9q or deletion in 16q are important in EATL pathogenesis[2]. Following the new WHO classifcation of lymphoid neoplasms Type 2EATL has been reclassifed as monomorphic epitheliotropic intestinal T-celllymphoma (MEITL) [1]. MEITL is less commonly associated with coeliacdisease and is characterized by a monomorphic infltrate of small- tomedium-sized lymphoma cells. CD30 is often negative in MEITL, and CD56positivity suggests that a di?erent mechanism underlies the lymphomagenicprocess of this tumour in contrast to EATL [2].