Abstract：The antipsychotics drugs may cause further liver damage of patients with liver cirrhosis and mental disorders. This paper reviewed the clinical data of 5 patients with liver cirrhosis and mental disorders, and to analyze the potential reasons of recurring wake-up after a coma. The recurring wake-up after a coma might connect with issues such as drug accumulation, increased drug dosage without medical orders, chronical constipation, and so on. It is necessary to chose antipsychotics drugs with minimal side effects. Nursing interventions on medication, diet, monitoring consciousness, health education and chronical constipation are also required to prevent the recurring wake-up after a coma.
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