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RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation

机译:RNA聚合酶II转录延伸和Pol II CTD Ser2磷酸化

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The transition between initiation and productive elongation during RNA Polymerase II (Pol II) transcription is a well-appreciated point of regulation across many eukaryotes. Elongating Pol II is modified by phosphorylation of serine 2 (Ser2) on its carboxy terminal domain (CTD) by two kinases, Bur1/Ctk1 in yeast and Cdk9/Cdk12 in metazoans. Here, we discuss the roles and regulation of these kinases and their relationship to Pol II elongation control, and focus on recent data from work in C. elegans that point out gaps in our current understand of transcription elongation.
机译:RNA聚合酶II(Pol II)转录过程中起始和生产伸长之间的过渡是许多真核生物之间公认的调控点。延长的Pol II通过两个激酶(酵母中的Bur1 / Ctk1和后生动物的Cdk9 / Cdk12)磷酸化其羧基末端结构域(CTD)上的丝氨酸2(Ser2)进行修饰。在这里,我们讨论了这些激酶的作用和调节及其与Pol II延伸控制的关系,并将重点放在来自C的最新数据中。线虫指出了我们目前对转录延伸的理解方面的差距。

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