Assessment of novel pyrazolopyridinone fused imidazopyridines as potential antimicrobial agents

摘要

The antimicrobial activity of pyrazolopyridinone fused imidazopyridines was investigated against various Gram-positive and Gram-negative bacteria as well as fungal strains using Ofloxacin and Fluconazole as positive controls, respectively. Interestingly, all the derivatives displayed good to excellent antibacterial activities against all bacterial strains with MIC values ranging from 25 to 0.39?μg/mL; compounds 3aA and 4dA displaying even better activity against Staphylococcus epidermidis than the positive control (MIC?=?1.25?μg/mL). These derivatives also proved to be effective antifungal agents with MICs ranging from 12.5 to 0.39?μg/mL; compounds, 3aA and 4dA being most potent antifungal representatives against Candida albicans in comparison to the reference drug Fluconazole (MIC?=?0.39?μg/mL). The SARs associated with different diversity points of these derivatives have also been discussed. Graphical abstract Display Omitted.