P22 A NOVEL METHOD FOR HIGH-THROUGHPUT DETECTION AND QUANTIFICATION OF NEUTROPHIL EXTRACELLULAR TRAPS REVEALS ROS-INDEPENDENT NET RELEASE WITH IMMUNE COMPLEXES

摘要

We have recently characterized Foxp3+ regulatory Tcells, co-expressing the Th17 characteristic transcription factorROR t, as an independent and bi-functional T cell lineage (biTregs).biTregs secrete both, anti-inflammatory (IL-10, IL-35), but also proinflammatory (IL-17) cytokines. Studies in a model of acute crescentic glomerulonephritis have suggested that pro- inflammatorybiTreg functions are largely mediated by ROR t.