IgA-Dominant Acute Postinfectious Glomerulonephritis Presenting as Acute Renal Failure in a Kidney Transplant Recipient

摘要

I gA-dominant acute postinfectious glomerulone- phritis (APIGN) is a morphologic variant of APIGN inwhich IgA is the dominant or co-dominant Ig found inglomerular immune deposits. It is a rare disease and, toour knowledge, has not been previously reported in akidney transplant recipient. Here we describe a caseof IgA-dominant APIGN that developed in an immunosuppressed kidney transplant recipient despite appropriate antibiotics and source control of his infectionwith limb amputation. He presented with severe renalfailure after a bout of Staphylococcus aureus septicemia.Early biopsy and subsequent recognition of the diseaseled to empiric steroid therapy that ultimately resultedin renal recovery.