T-Cell/Histiocyte Rich Large B-Cell Lymphoma –A Case Series with Review of Literature

摘要

T-Cell/Histiocyte Rich Large B-Cell Lymphoma (THRLBCL) is a rare variant of Diffuse Large B Cell Lymphoma (DLBCL). This entity differs from the classical DLBCL in the morphology as well as immunohistochemical expression of various CD markers. This lymphoma is characterized by paucity of large, atypical B-cells and surrounded in the background by a dense population of reactive T-cells and histiocytes. This lymphoma gains importance in differentiation from the classical DLBCL in that it is morphologically very similar to the Nodular Lymphocyte Predominant Hodgkin lymphoma (NLPHL). THRBCL is often refractory to the current line of treatment available. Hence, identification of this entity with the help of immuohistochemical and molecular studies is essential for the correct diagnosis and management. Here in this study, we report a series of four cases which are diagnosed as THRLBCL along with review of the literature.