Microelectronic neural bridging of toad nerves to restore leg function

摘要

The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to restore the lost function of one nerve. The left leg of one spinal toad was subjected to external mechanical stimulation and functional electrical stimulation driving. The function of the left leg of one spinal toad was regenerated to the corresponding leg of another spinal toad using a microelectronic neural bridge. Oscilloscope tracings showed that the electromyographic signals from controlled spinal toads were generated by neural signals that controlled the spinal toad, and there was a delay between signals. This study demonstrates that microelectronic neural bridging can be used to restore neural function between different injured nerves. Research Highlights (1) A microelectronic neural bridge was built comprising electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit. (2) The spinal toad animal model does not inhibit generation and transmission of neural signals or inhibit neural signals generated by functional electrical stimulation. The entire body can maintain biological activity free of control by the brain. (3) With the help of microelectronic neural bridge, the function of the left leg of one spinal toad can restore the function on the corresponding leg of another spinal toad.