Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells

摘要

Diabetes mellitus (DM) is an increasingly prevalent group of metabolic diseases affecting hundreds of millions of people worldwide and costing billions of dollars in healthcare. This heterogeneous group of disorders is characterized by hyperglycemia [1] and results from absolute insulin deficiency, insulin resistance and/or abnormal insulin secretion [2]. DM may lead to a series of complications including blindness, renal failure, nerve damage, stroke, and limb amputation [3]. In 2012, there were approximately 4.8 million deaths resulting from DM with 471 billion USD spent on healthcare costs globally. Approximately 371 million people today have DM [4].