Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

摘要

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113?g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes ( 1 – 8 ) were isolated from the mother liquid. The chemical structures of new compounds ( 1 – 4 ) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC _(50) values ranging from 4.02 to 15.80? μ M. Graphic Abstract Electronic supplementary material The online version of this article (10.1007/s13659-019-0214-1) contains supplementary material, which is available to authorized users.