Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus at Tertiary Care Centre

摘要

Background: The aim of the present study was to find the prevalence of thyroid dysfunction in patients with type 2 diabetes mellitus (type 2 DM) attending an outpatients department and medical wards in Dr D Y Patil Medical College and Hospital. Materials and Methods: Data of 50 diabetic and 50 non diabetic patients who attended OPD and admitted in medical wards of Dr D Y Patil Medical College and Hospital, pimpri, pune from September 2012 to September 2013. These subjects were investigated for total triidothyronine (T3), total thyroxin (T4), thyroid stimulating hormone (TSH), Fasting Blood Sugar(FBS), glycosylated hemoglobin (HbA1c), serum cholesterol, serum triglycerides, high density lipoprotein(HDL), low densit lipoprotein(LDL), very low density lipoprotein(VLDL), blood urea, serum creatinine. Results: The level of T3and T4were significantly lower while the level of TSH was significantly higher in type 2 diabetics as compared to non-diabetics. From the 50diabetic subjects studied, 30% showed abnormal thyroid hormone levels (22 % had hypothyroidism and 8 % had hyperthyroidism). Significantly higher levels of FBS, HbA1c, serum cholesterol, serum triglyceride, LDL, VLDL, blood urea, creatinine, and significantly lower level of HDL was observed in diabetics as compared to non-diabetics subjects. Conclusion: The prevalence of thyroid dysfunction among type 2 DM patients is very high (30 %) with subclinical hypothyroidism is being most common. All patients with type 2 DM should be screened for thyroid dysfunction to reduce the mortality rate.