A clinical study on the anti-Hypertensive effect of cilazapril in patients with mild to moderate essential hypertension

摘要

Background In order to investigate the efficacy and safety of cilazapril, a recently developed angiotensin converting enzyme inhibitor, a clinical study was performed in the patients with mild to moderate essential hypertension. Methods The study subject consisted of 31 patients with diastolic blood pressure of 95mmHg~115mmHg (mean age : 56.0±8.1 years, 16 males and 15 females). Cilazapril was administered orally in a daily dose of 2.5mg~5.0mg Q.D. for 8 weeks. During cilazapril medication, anti-hypertensive efficacy, side effects and laboratory changes were monitored. Results Cilazapril decreased blood pressure from baseline value of 162.2±4.7/98.4±2.8mmHg to 144.6±10.0/89.7±5.7mmHg after 4weeks of medication (p Conclusions Cliazapril 2.5mg~5.0mg once daily regimen was effective and well tolerated in patients with mild to moderate essential hypertension.