Study on Serum Lipoprotein Patterns in Normal Korean and in the Patients with Cardiovascular Diseases

摘要

Serum lipoprotein patterns were studied in 78 normal persons and in the following patients; 79 patients with hypertension, 21 patients with cerebrovascular accident, 10 patients with myocardial infarction, 18 patients with diabetes mellitus, 10 patients with nephrotic syndrome, and 10 patients with chronic renal failure. The serum lipoproteins were separated by electrophoresis on cellulose acetate which gives high resolution of chylomicron, β-lipoprotein, pre-β-lipoprtoein and α-lipoprotein. Lipoproteins were stained by Oil Red O saturated in 60% ethanol, and each fraction was cut and eluted for spectrophotometric determination. The results obtained are summarized as follows. 1. In normal Korean, serum α-lipoprotein showed decrement with aging, while serum β-lipoprotein increasesd with aging, but the difference was not statistically significant. No significant alteration by sex in serum lipoprotein patterns were observed. Pre-βlipoprotein was observed in 28.6% of normal Korean under the age of 30, and about 50% of normal Korean over the age of 30. 2. Serum β-lipoprotein was higher significantly in the patients with myocardial infarction than in normal control subjects. 3. Serum β-lipoprotein in the patients with essential hypertension was significantly higher than in normal control subjects. Serum lipoprotein patterns were, however, not statistically different by both sex and age in essential hypertension, It was observed that increased serum β-and pre-β-lipoprotein in essential hypertension was closely related with the intensity of albuminuria. 4. No significant difference in the serum lipoprotein patterns between normal control and the patients with cerebrovascular accident was observed. 5. In patients with diabetes mellitus, marked increase in the serum β- and pre-β-lipoprotein was observed. 6. in the patients with nephrotic syndrome, the increase in the serum β-and pre-β-lipoprotein was marked, and markedly increased pre-β-lipoprotein was the case in more than half of the patients as compared to the other groups. 7. No difference was observed in the composition of polar lipids between the patients with various diseases (essential hypertension, diabetes mellitus and cerebrovascular accident) and normal person.