Clinical and Echocardiographic Changes after Short-Term Denopamine (Cardopamin?) Therapy in Patients with Chronic Congestive Heart Failure

摘要

Background Inotropic agents have been shown to improve cardiac function in patients with congestive heart failure. The purpose of the present study is to evaluate the short-term efficacy and safety of denopamine(Cardopamin?), and orally available β-stimulant, in patients with chronic congestive heart failure. Subjects and Methods Twenty-four patients(54.1±10.9 years, male:female=1.4:1) with chronic congestive heart failure whose functional classes were equal or greater than New York Heart Association(NYHA) Class II were enrolled in this study after informed consents were obtained. Upon completion of baseline evaluation, denopamine(Cardopamin?) was administered orally, startion with 15 mg per day and increased to 30 mg per day according to the clinical response of each patient. Blood pressure, heart rate, electrocardiographic(EKG) findings, AST, BUN, and creatinine were also followed up at 4 weeks' interval. The clinical effects and side effects at 4 weeks' interbal and echocardiographic examination at baseline and 8 weeks after trentment were evaluated. Results Mean dosage of denopamine(Cardopamin?) was 22.9±5.3mg per day. The clinical symptoms of 18(75%) of 24 patients were improved. The echocardiographic follow-up revealed a significant decrease in left vetricular(LV) end-Systolic dimemsion(fron 4.8±0.2mm to 4.5±0.1mm. p Conclusion Above results suggest that short-term therapy of denopamine(Cardopamin?) may improve clinical symptom with no side effect in patients with chronic congestive heart failure, but the long-term efficacy remains to be determined with a randomized long-term follow up study.