Clinical Trial on the Hypotensive Effect of Carteolol

摘要

The clinical trial was carried out with carteolol in 30 patients with essential hypertension. The results were as follows : 1) Before medication and after 2,4,6 and 8 weeks of medications, the overall average systolic and diastolic blood pressure were 175±17.7/105±9.3, 144±8.9/92±6.9, 143±11.2/90±6.6, 141±8.4/88±6.9, and 142±9.0/88±7.1 mmHg. As a result, blood pressure significantly fell with carteolol treatment. 2) In 80± of all cases, marked or moderate degree of hypotnesive effect was observed within 2 weeks of treatment. 3) Before medication and after 2, 4, 6 and 8 weeks of medication, the overall average heart rates were 75±11.8, 73±9.0, 71±8.7, 71±8.2 and 71±8.6 beats/minute. There was no significant changes in heart rates before and after treatment. 4) Dizziness or fatigability were complained in 4 patients (13±) each while receiving carteolol. These side effects were mild in 3 patients, but one patient discontinued treatment due to dizziness. On the basis of these results, carteolol was evaluated to be promising hypotensive drug.