Quinone Methides (Part I): Reactive Intermediates in the Chemistry of Phenols and Their Application in Organic Synthesis

摘要

Quinone methides (QMs, IUPAC name: quinomethanes) are reactive intermediates which are very important in organic chemistry. Their applications in organic synthesis are widely recognized, which has led to the development of a large number of methods for their generation. They are useful in stereoselective reactions, which open them the way for applications in total synthesis, often for structures that have already shown significant biological activity. This review gives an insight into the methods of synthetic (thermal) generation of QMs and their applications in organic synthesis, with an emphasis on the biological activity of QMs or the products obtained from them in the synthesis.