Association of SNPs and haplotypes in GABAA receptor |[beta]|2 gene with schizophrenia

摘要

Disturbances in GABAergic system have been observed in schizophrenics.1,2,3 In the present study, population association analysis was performed on 19 SNPs in the 1, 2, 2, and subunit genes of GABAA receptor. Five SNPs in GABRB2, namely B2I7G1584T, rs1816071, rs194072, rs252944 and rs187269, were found to be significantly associated, and their haplotypes in linkage disequilibrium, with schizophrenia. This represents the first report on any disease association of SNPs in the human GABAA receptor genes, and focuses attention on the GABAergic hypothesis of schizophrenia etiology.3,4