GC-MS analysis and antibacterial activity of some fractions from Lagochilus ilicifolius Bge. grown in Mongolia

摘要

3-methyl-1,2,3,4-tetrahydroquinoline ( 1 ), 4-hydroxyisoquinoline ( 2 ), 4-(1E)-hydroxy-1-prophenyl)-2-methoxyphenol ( 3 ), 4-acetoxycinnamic acid ( 4 ), Songoramine ( 5 ), and Songorine ( 6 ) have been determined by GC-MS analysis from the crude alkaloid mixtures (G 1 ) obtained from the aerial parts of Lagochilus ilicifolius Bge. grown in Mongolia and comparison of the measured data with those from the literature. The compounds 1 - 6 are described for the first time from L.ilicifolius . From these 3-methyl-1,2,3,4-tetrahydroquinoline ( 1) was determined for the first time from natural plants. In addition, the antibacterial activity of fractions and total alkaloids were evaluated against Staphylococcus aurous , Bacillus subtilis , Bacillus cereus and Escherichia coli strains, respectively. The growth inhibition zones against gram-positive S.aureus , B.subtilis , B.cereus and gram negative E.coli , strains were observed. Positive results were achieved on 500 μg/disc concentration, but lower results or no active on 100 μg/disc concentration were for the plant extracts, fractions and total alkaloids. Mongolian Journal of Chemistry 16 (42), 2015, 39-43.