Changes in the Expression of Insulin Signaling Pathway Molecules in Endometria from Polycystic Ovary Syndrome Women with or without Hyperinsulinemia

摘要

Polycystic Ovary Syndrome (PCOS) is a steroid-related disorder that affects between 5–10% of reproductive aged women. PCOS affects endocrine metabolism and is linked with insulin resistance and compensatory hyperinsulinemia. However, little is known about the expression of insulin pathway molecules in endometrial tissue from women diagnosed with PCOS. Fornes et al . examined the levels of several insulin signaling proteins in endometrial from PCOS women with or without hyperinsulinemia. The authors found that the endometrium expresses insulin-sensitive glucose uptake machinery, and that some proteins which belong to insulin signaling pathway show a significantly reduced expression in PCOS patients with hyperinsulinemia. This alteration suggests a disruption in the insulin signaling pathway which may account for impairment in glucose metabolism and homeostasis at the endometrial level.