Oncomodulin and macrophages derived factors in pancreas injury and development paradigms

摘要

Prior studies in the optic nerve injury paradigm showed con?icting data regarding production and signi?cance of the Ca2+-binding protein oncomodulin (OCM). Some have shown its potentaxon-regenerative or-growth attribute, where other showed little to no effect. We show here that pancreas inflammation lead to macrophages infiltration that produce OCM and inflamed tissues that express OCM receptorsin vivo. In culture OCM has a cytostatic effect on embryonic pancreas explants. Secretory products of zymosan activated macrophages are cytotoxic and factors derived from non-activated macrophages seem to promote pancreas development. It is our view that OCM is involved in protective injury response that allows through metabolism slowing sublethally injured cells to undergo recovery.