Occupational contact allergy to omeprazole and ranitidine

摘要

Omeprazole is a proton pump inhibition and ranitidine is an H2 histamine receptor antagonist widely used in the treatment ofgastroesophageal reflex disease, peptic ulcer disease, Zollinger-Ellison syndrome and as a protector of the gastric mucosae. We reporta case of occupational contact allergy to omeprazole and ranitidine. A 48-year-old man, with no pre-existing history of atopyor lifestyle factors. He neither had any medical history of consumption of drugs such as ranitidine and omeprazole. He workedfor 19 months in the pharmaceutical company that manufactured ranitidine base. He presented rash in the face and eczema onthe dorsum of the hands with itching. The study by prick tests with ranitidine gave negative response. Patch testing with ranitidinebase and ranitidine hydrochloride gave positive response. A month later, when the patient was asymptomatic he returned to thepharmaceutical company, being switched from this previous job to the reactor manufacturing omeprazole. A few days after that,he presented erythematous eruptions involving face and neck with itching. Prick tests, path tests and in vitro laboratories studieswith omeprazole gave positives. In this case the patient presented hypersensitivity type I at omeprazole and hypersensitivitytype IV at omeprazole and ranitidine. Our aportation indicates the importance of careful analysis of the occupational exposurehistories of patients with the suspected type I or type IV hypersensitivity to allergens, to determine whether work exposure is thecause. Med Pr 2017;68(3):433–435