The analysis of factors associated with improved glycemic con- trol in patients with insulin- requiring type 2 diabetes mellitus after treatment

摘要

Aim To observe the effect of standardized ten-day diabetes preventionand control program on glycemic control, and to analyzefactors contributing signiicantly to improvement of glycemic controlafter the program/intervention.Methods A cross-sectional nested case–control study on 91 adultpatients with insulin-requiring type 2 diabetes mellitus who underwenta standardized ten-day diabetes program in the SpecializedHospital “Merkur” in Vrnja?ka Banja, Serbia, from June the 1stto August 1st 2010 was performed. All necessary data were obtainedfrom patients’ medical iles archived in this institution. Cases(n=32) and controls (n=32) were matched for age and sex.Results Diabetes program led to a signiicant decrease in meandaily blood glucose (p=0.039), achieved at the expense of the reductionof postprandial hyperglycemia (p=0.013). Male patients,patients with mean daily glycemia above the acceptable range beforethe intervention, and patients who were receiving combinedtherapy (insulin plus oral antidiabetics) before the intervention,were signiicantly more likely to achieve such positive outcome(ORadjusted = 344.48, 12.83, and 25.44 respectively, with 95%CIsthat not included 1).Conclusion Standardized ten-day diabetes educational and rehabilitationprogram in the Specialized Hospital “Merkur” could beeficient in improving glycemic control, especially for male patientswhose glucoregulation was poor despite the combined therapywith insulin and oral antidiabetic agents. Further investigationon determinants of eficiency of this program are necessary tounderstand better how to facilitate and support improvements indiabetes control at the population level