Monoinfections caused by Borrelia burgdorferiand Borrelia burgdorferi / Anaplasma phagocytophilum co-infectionsin forestry workers and farmers

摘要

Background: The presence of co-infections induced by tick-borne pathogens in humans is an important epidemiological phenomenon.This issue has attracted growing attention of doctors and people working under conditions of an increased risk of being exposedto tick bites. Material and Methods: The research group consisted of 93 individuals with current anti-immunoglobulin M/G (IgM/IgG) Borrelia burgdorferi or IgG anti-Anaplasma phagocytophilum. The respondents were identified during the screening survey ina group of farmers and foresters occupationally exposed to tick bites. The aim of the work was to analyse the frequency of antibodiesto specific antigens of B. burgdorferi and the levels of cytokines in forestry workers and farmers with B. burgdorferi monoinfectionsand B. burgdorferi / A. phagocytophilum co-infections. Statistical analysis was performed using the Chi2, Mann-Whitney U andKruskal-Wallis tests. Results: There is a stronger generation of IgG antibodies to B. burgdorferi antigens in patients with B. burgdorferi/ A. phagocytophilum co-infections, such as variable major protein-like sequence expressed (VlsE) (p 0.05), p19 (p 0.02), p17(p 0.05) and complement regulator-acquiring surface protein 3 (CRASP3) (p 0.02) compared to persons with B. burgdorferi monoinfections.The discrepancies in the synthesis of cytokines interleukin 6 (IL-6), IL-10, and tumor necrosis factor α (TNF-α) havenot been found in persons with B. burgdorferi monoinfections and B. burgdorferi / A. phagocytophilum co-infection. Conclusions: The immune response directed against B. burgdorferi is stronger in patients co-infected with B. burgdorferi and A. phagocytophilumthan in those with monoinfection. Med Pr 2015;66(5):645–651