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首页> 外文期刊>Mediterranean Journal of Hematology and Infectious Diseases >PROGNOSTIC SIGNIFICANCE AND TREATMENT IMPLICATIONS OF MINIMAL RESIDUAL DISEASE STUDIES IN PHILADELPHIA-NEGATIVE ADULT ACUTE LYMPHOBLASTIC LEUKEMIA
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PROGNOSTIC SIGNIFICANCE AND TREATMENT IMPLICATIONS OF MINIMAL RESIDUAL DISEASE STUDIES IN PHILADELPHIA-NEGATIVE ADULT ACUTE LYMPHOBLASTIC LEUKEMIA

机译:费城阴性成人急性淋巴细胞性白血病最小残留病研究的预后意义和治疗意义

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摘要

Acute lymphoblastic leukemia (ALL) is curable in about 40-50% of adult patients, however this is subject to ample variations owing to several host- and disease-related prognostic characteristics. Currently, the study of minimal residual disease (MRD) following induction and early consolidation therapy stands out as the most sensitive individual prognostic marker to define the risk of relapse following the achievement of remission, and ultimately that of treatment failure or success. Because substantial therapeutic advancement is now being achieved using intensified pediatric-type regimens, MRD analysis is especially useful to orientate stem cell transplantation choices. These strategic innovations are progressively leading to greater than 50% cure rates.
机译:约40-50%的成年患者可治愈急性淋巴细胞性白血病(ALL),但是由于几种与宿主和疾病相关的预后特征,该疾病容易发生广泛变化。当前,对诱导和早期巩固治疗后的最小残留疾病(MRD)的研究是最敏感的个体预后指标,用于定义缓解实现后复发的风险,最终定义治疗失败或成功的风险。因为现在使用强化的儿科型治疗方案已经取得了实质性的治疗进展,所以MRD分析对于确定干细胞移植的选择特别有用。这些战略创新逐渐使治愈率超过50%。

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