Decreased levels of plasma adiponectin in prediabetes, Type 2 Diabetes and coronary artery disease.

摘要

Background: Adiponectin, an adipocyte-derived hormone is implicated ininsulin resistance and atherosclerosis. The aim of our study is to compare the levels of adiponectinin subjects with prediabetes and diabetes with subjects with normal glucose. Material/Methods: In a crosssectional study, we measured adiponectin and insulin in addition to fasting lipid panel and glucose in28 subjects with prediabetes, 28 subjects with normal fasting glucose and 33 subjects with type 2 diabetes.Results: Adiponectin levels negatively correlate with insulin resistance index ([i]r[/i]=-32.7). There is asignificant difference in the levels of adiponectin between subjects with prediabetes and normal fastingglucose. There is a significant difference in adiponectin levels in subjects with prediabetes with Coronaryartery disease (CAD) compared to those without CAD (10.24+/-1.02 vs. 7.02+/-0.92 with [i]p[/i]