Genomics in Acute Myeloid Leukemia: From Identification to Personalization

摘要

Acute Myeloid Leukemia (AML) is an aggressive bone marrow malignancy that is fatal if left untreated. Pre- vious classification was strictly based on morphology, which gave little information in terms of prognosis or guide to treatment. Recent research has provided vital information into the chromosomal and molecular patho- genesis of leukemia development. The discovery of these abnormalities via proteomics and genomics have provid- ed two key insights. First, these novel discoveries pro- vide prognostic significance into the predictive result of chemotherapy. Second, these chromosomal and protein abnormalities have provided potential drug targets for new treatment modalities. This article will elaborate on many of these new molecular findings and discuss their implications on the treatment of AML.