Women & Infants researchers examine role of hormone in patient responses to ovarian cancer treatment

摘要

PROVIDENCE – Researchers at Women & Infants Hospital of Rhode Island recently published the results of an investigation into how we might better tailor therapy for ovarian cancer. The work comes out of the molecular therapeutic labo- ratory directed by RICHARD G. MOORE, MD , of Women & Infants' Program in Women's Oncology. Entitled "HE4 expression is associated with hormonal elements and medi- ated by importin-dependent nuclear translocation," the research was recently published in the international science journal Scientific Reports, a Nature publishing group. The goal of the study was to investigate the role of the hormone HE4 in modulating an ovarian cancer's response to hormones and hormonal therapies. HE4 is a biomarker that is elevated in ovarian cancer and is known to play a role in resistance to chemotherapy.