PPAR-α Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia

摘要

BACKGROUND Regulated upon activation, normal T cells expressed and secreted (RANTES) is associated with inflammation and atherosclerosis. We investigated the effect of fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, on RANTES in type 2 diabetes mellitus (T2DM) patients with hypertriglyceridemia. MATERIAL AND METHODS This study evaluated cross-sectional and interventional studies of 25 T2DM patients with hypertriglyceridemia (group A) and 32 controls (group B). Group A was treated with fenofibrate (200 mg/day) for 8 weeks. Serum RANTES and clinical characteristics were examined. RESULTS Serum RANTES was significantly higher in group A compared with group B (59.04±16.74 [i]vs.[/i] 38.57±12.98 ng/ml, [i]P[/i]<0.001) and correlated with triglycerides (TG) (r=0.535, [i]P[/i]<0.001), fasting blood glucose (FBG) (r=0.485, [i]P[/i]<0.001), glycosylated hemoglobin (HbA1c) (r=0.485, [i]P[/i]<0.001), homocysteine (Hcy) (r=0.520, [i]P[/i]<0.001), and high-sensitivity C-reactive protein (hsCRP) (r=0.701, [i]P[/i]<0.001). In multiple regression analysis after controlling for confounders, increased hsCRP levels (β=7.430, [i]P[/i]<0.001) and T2DM with hypertriglyceridemia (β=11.496, [i]P[/i]=0.002) were independently related to high serum RANTES levels. After 8 weeks of fenofibrate treatment, serum RANTES significantly decreased in group A compared with baseline (52.75±17.41 [i]vs[/i]. 59.04±16.74 ng/ml, [i]P[/i]=0.018). CONCLUSIONS Fenofibrate decreased serum RANTES levels in T2DM patients with hypertriglyceridemia, indicating that PPAR-a agonists may play an important role in inhibiting inflammatory responses.