Immunologic and immunobiochemical features of uveitis at Vogt-Koyanagi-Harada syndrome

摘要

The purpose of our research is to study immunologic and immunobiochemical indicators at patients with VKH syndrome. 35 pairs of eyes (21 patients aged from 16-42 years) with Vogt-Kayanagi-Harada (VKH) syndrome and 13 almost healthy faces were surveyed. At all patients along with the standard ophthalmologic inspections there were investigated immunologic and immunobiochemical indicators of a peripheral blood. The uveitis at a syndrome of VKH is characterized by the changes of cellular immunity which were more expressed at an excavation and complication of inflammatory process. The significant role in a uveitis pathogenesis at a syndrome of VKH is played by autoimmune process that proves accumulation in blood serum of excess concentration of circulating immune complexes and immunoglobulins of classes G and M. Studying of immune mechanisms of a uveitis at VKH syndrome opens new opportunities for well-timed diagnostics and pathogenetically focused therapy of this disease.