首页> 外文期刊>Frontiers in Behavioral Neuroscience >Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions
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Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions

机译:急性精神病中的前肢边缘性新奇处理:与记忆表现的关系中断以及对妄想的潜在影响

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Recent concepts have highlighted the role of the hippocampus and adjacent medial temporal lobe (MTL) in positive symptoms like delusions in schizophrenia. In healthy individuals, the MTL is critically involved in the detection and encoding of novel information. Here, we aimed to investigate whether dysfunctional novelty processing by the MTL might constitute a potential neural mechanism contributing to the pathophysiology of delusions, using functional magnetic resonance imaging (fMRI) in 16 unmedicated patients with paranoid schizophrenia and 20 age-matched healthy controls. All patients experienced positive symptoms at time of participation. Participants performed a visual target detection task with complex scene stimuli in which novel and familiar rare stimuli were presented randomly intermixed with a standard and a target picture. Presentation of novel relative to familiar images was associated with hippocampal activation in both patients and healthy controls, but only healthy controls showed a positive relationship between novelty-related hippocampal activation and recognition memory performance after 24 h. Patients, but not controls, showed a robust neural response in the orbitofrontal cortex (OFC) during presentation of novel stimuli. Functional connectivity analysis in the patients further revealed a novelty-related increase of functional connectivity of both the hippocampus and the OFC with the rostral anterior cingulate cortex (rACC) and the ventral striatum (VS). Notably, delusions correlated positively with the difference of the functional connectivity of the hippocampus vs. the OFC with the rACC. Taken together, our results suggest that alterations of fronto-limbic novelty processing may contribute to the pathophysiology of delusions in patients with acute psychosis.
机译:最近的概念已经强调了海马和邻近的颞中叶(MTL)在精神分裂症的妄想等积极症状中的作用。在健康个体中,MTL至关重要地参与了新信息的检测和编码。在这里,我们旨在通过功能性磁共振成像(fMRI)对16名偏执型精神分裂症的未药物治疗的患者和20个年龄相匹配的健康对照者进行研究,以探讨MTL对功能异常的新奇加工是否可能构成导致妄想的病理生理的潜在神经机制。所有患者在参与时均出现阳性症状。参与者执行具有复杂场景刺激的视觉目标检测任务,其中将新颖和熟悉的稀有刺激随机与标准和目标图片混合显示。在患者和健康对照者中,相对于熟悉图像的新颖呈现均与海马激活有关,但只有健康对照显示24小时后新奇相关海马激活与识别记忆性能之间呈正相关。在呈现新型刺激的过程中,患者(而非对照组)在眶额叶皮层(OFC)中显示出强大的神经反应。患者的功能连通性分析进一步显示,与海马和OFC的前缘扣带回皮层(rACC)和腹侧纹状体(VS)的新颖性相关的增加。值得注意的是,妄想与rACC对海马与OFC的功能连通性的差异呈正相关。综上所述,我们的结果表明额叶新奇过程的改变可能有助于急性精神病患者的妄想的病理生理。

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