As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter.The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions are determined, has already long and strongly been challenged.It is in fact well recognised that multi-level causality with feedback cyclesamongallformerandnewlyidenti?edbiochemicallevels(includingsmallRNAs,epigenomic changes) is a fundamental attribute of biological systems (Noble, 2012).
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