EVALUATION OF THE EFFECT OF SULPIRIDE AS AN ATYPICAL ANTIPSYCHOTIC DRUG ON THE SERUM LEVELS OF PROLACTIN, LH, FSH AND TESTOSTERONE IN ADULT MALE RATS

摘要

Background & Aims: Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic patients was increased because of their less side effects. This study was aimed to evaluate the effect of sulpiride on serum level of prolactin and sexual hormones. Materials & Methods: Twenty three adult male mice were divided in three groups as test, control sham and control. The test mice were received sulpiride solution, daily for 45 days IP. Mice in the control sham were received the solvent only. Sample blood gathered and level of prolactin, LH, FSH and testosterone were measured in the serum samples of all 3 groups and data was analyzed. Results: A significant increase in serum prolactin levels was found in the treated mice which were along with a significant decrease of LH, FSH and testosterone levels. Conclusion : These findings indicate that sulpiride is able to induce prolactin reproductive dysfunctions that by this induce and increase in proluctin level can control sexual hormones and disorder normal functioning of the reproductivity.