PERBEDAAN KADAR MALONDIALDEHID PLASMA DARAH ANTARA PENDERITA KATARAK SENILIS IMATUR DAN MATUR PADA PASIEN KLINIK MATA RUMAH SAKIT MARGONO SOEKARJO

摘要

Senile cataract is the leading cause of blindness and one of the factor in pathogenesis of senile cataract is oxidative stress. Oxidative stress through lipid peroxidation can occur in the first phase of pathogenesis of senile cataract. Malondialdehyde is the secondary product of lipid peroxidation that used as a biomarker of oxidative stress. The aim of this study was to determine the difference of plasma malondialdehyde level between immature and mature senile cataract pastient in Ophtalmology Department of Margono Soekarjo Hospital. This study conducted in Ophtalmology Department of Margono Soekarjo Hospital, Purwokerto, starting in April until May 2015. This was a case control study with 20 subjects, 10 subjects in each group of immature and mature senile cataract. Bivariable analysis was done by using Independent t Test with significance rate p=0,05. The mean level of plasma malondialdehyde were 0,401±0,13μmol/L in immature senile cataract and 0,468±0,12μmol/L in mature senile cataract. Bivariable analysis showed that the difference of plama malondialdehyde between immature senile cataract and mature senile cataract (p0,05) with p = 0,251 is statistically insignificant. The conclusion was there is no difference of plasma malondialdehyde of immature senile cataract and mature senile cataract patient in Ophtalmology Department of Margono Soekarjo Hospital.