The last few decades have seen significant improvements in the capabilities of gastrointestinal endoscopy. One example is the ability to gain access to the second space (peritoneal cavity) and the third space (intramural or submucosal space). In this month’s issue of Gastroenterology & Hepatology, one of our feature articles highlights recent developments in the operating field of third-space endoscopy. Dr Zaheer Nabi, Dr D. Nageshwar Reddy, and Dr Mohan Ramchandani examine peroral endoscopic myotomy, submucosal tunneling endoscopic resection, gastric peroral endoscopic pyloromyotomy, and other third-space endoscopy procedures, with reference to possible adverse events that may occur and the various pieces of equipment and accessories that are needed for these procedures.
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